Abstract Search

ea0032p831 | Pituitary–Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Chracterizazion of somatostatin receptor expression in MENX-assoxciated pituitary adenomas: impact on therapy and imaging with somatostatin analogs

Lee Misu , Lupp Amelie , Gartner Florian , Castano Justo P , Schulz Stephan , Pellegata Natalia

Introduction: Somatostatin analogs (SSAs) are the first-line clinical treatment for patients with pituitary adenomas (PAs) but their efficacy is highly variable among patients. This could be due to a differential expression of somatostatin receptor subtypes (Ssts) among tumors, but this issue is still unresolved. Nonfunctioning pituitary adenomas (NFPAs), which mostly derive from gonadotroph cells, are among the tumors that poorly respond to SSAs. Rats carrying a germline loss...

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ea0047oc15 | Spotlight on Neuroendocrine tumours | Theranostics2016

Evaluation of somatostatin, CXCR4 chemokine and endothelin a receptor expression in a large series of paragangliomas

Kaemmerer Daniel , Saenger Joerg , Arsenic Ruza , D'Haese Jan G. , Neumann Jens , Singh Aviral , Baum Richard P. , Schulz Stefan , Lupp Amelie

Background: Paragangliomas are predominantly benign tumors, but in some cases invasive growth and also metastasis is observed. Given the limited number of nonsurgical treatment options, novel target structures for diagnostics and therapy of this tumor entity are urgently needed.Aims: In the present study the expression of the five somatostatin receptor (SSTR) subtypes as well as of the chemokine receptor CXCR4 and of the endothelin receptor A (ETA) was e...

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Endocrine Abstracts

Chracterizazion of somatostatin receptor expression in MENX-assoxciated pituitary adenomas: impact on therapy and imaging with somatostatin analogs

Evaluation of somatostatin, CXCR4 chemokine and endothelin a receptor expression in a large series of paragangliomas

BiosciAbstracts